24 Correlation of clinical outcomes and poly ADP ribose polymerase activity in high grade serous ovarian cancer

• Päätekijät: Elaine T. Fleming (Tekijä), Hao Chen (Tekijä), Cristel Camacho (Tekijä), Donald McIntire (Tekijä), W. Lee Kraus (Tekijä), Jayanthi Lea (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2023-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Objectives: PARP proteins are regulators of DNA damage repair in the cell. PARP inhibitors (PARPi) are a class of drugs used to treat ovarian cancer especially in patients with BRCA 1/2 gene mutations and homologous recombination deficiencies. These have previously been used as biomarkers to predict...