Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell Disease

• Main Authors: Ellie H. Jhun (Author), Nilanjana Sadhu (Author), Xiaoyu Hu (Author), Yingwei Yao (Author), Ying He (Author), Diana J. Wilkie (Author), Robert E. Molokie (Author), Zaijie Jim Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16 single nucleotide polymorphisms (SNPs) covering 5&#...