mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections

• Main Authors: Lijun Fang (Author), Huaijun Tu (Author), Wei Guo (Author), Shixuan Wang (Author), Ting Xue (Author), Fei Yang (Author), Xiaoyan Zhang (Author), Yazhi Yang (Author), Qian Wan (Author), Zhexin Shi (Author), Xulong Zhan (Author), Jian Li (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The TSC1/2 heterodimer, a key upstream regulator of the mTOR, can inhibit the activation of mTOR, which plays a critical role in immune responses after bacterial infections. Monocytes are an innate immune cell type that have been shown to be involved in bacteremia. However, how the mTOR pathway is i...