DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma

• Main Authors: Sofia de Oliveira (Author), Ruth A. Houseright (Author), Benjamin G. Korte (Author), Anna Huttenlocher (Author)
• פורמט: ספר
• יצא לאור: The Company of Biologists, 2020-04-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Fibrolamellar carcinoma (FLC) is a rare liver cancer that affects adolescents and young adults. Genomic analysis of FLC has revealed a 400 kb deletion in chromosome 19 that leads to the chimeric transcript DNAJB1-PRKACA (DnaJ-PKAc), comprised of the first exon of heat shock protein 40 (DNAJB1) and e...