Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents

• Main Authors: Xin Zhang (Author), Qiang Liu (Author), Qianqian Li (Author), Yinghong Li (Author), Zhandong Liu (Author), Hongbin Deng (Author), Sheng Tang (Author), Yanxiang Wang (Author), Youchun Wang (Author), Danqing Song (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus (EBOV) activities. Structureactivity relationship analysis indicated: (i) 12N-dichlorobenzyl motif was beneficial for...