A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

• Main Authors: Blaise M. Costa (Author), Lina Cortés Kwapisz (Author), Brittney Mehrkens (Author), Douglas N. Bledsoe (Author), Bryanna N. Vacca (Author), Tullia V. Johnston (Author), Rehan Razzaq (Author), Dhanasekaran Manickam (Author), Bradley G. Klein (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results in the pathogenesis of neurological and psych...