Pharmacokinetics, Dose-Proportionality, and Tolerability of Intravenous Tanespimycin (17-AAG) in Single and Multiple Doses in Dogs: A Potential Novel Treatment for Canine Visceral Leishmaniasis

• Main Authors: Marcos Ferrante (Author), Bruna Martins Macedo Leite (Author), Lívia Brito Coelho Fontes (Author), Alice Santos Moreira (Author), Élder Muller Nascimento de Almeida (Author), Claudia Ida Brodskyn (Author), Isadora dos Santos Lima (Author), Washington Luís Conrado dos Santos (Author), Luciano Vasconcellos Pacheco (Author), Vagner Cardoso da Silva (Author), Jeancarlo Pereira dos Anjos (Author), Lílian Lefol Nani Guarieiro (Author), Fabiana Landoni (Author), Juliana P. B. de Menezes (Author), Deborah Bittencourt Mothé Fraga (Author), Aníbal de Freitas Santos Júnior (Author), Patrícia Sampaio Tavares Veras (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the New World, dogs are considered the main reservoir of visceral leishmaniasis (VL). Due to inefficacies in existing treatments and the lack of an efficient vaccine, dog culling is one of the main strategies used to control disease, making the development of new therapeutic interventions mandato...