Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease.

• Main Authors: Paola Rosa Luz (Author), Márcia I Miyazaki (Author), Nelson Chiminacio Neto (Author), Marcela C Padeski (Author), Ana Cláudia M Barros (Author), Angelica B W Boldt (Author), Iara J Messias-Reason (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement. MBL levels and protein activity are affected by polymorphisms in the MBL2 gene. We sequenced...