Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

• Asıl Yazarlar: Lorenzo Turcano (Yazar), Esther Torrente (Yazar), Antonino Missineo (Yazar), Matteo Andreini (Yazar), Marina Gramiccia (Yazar), Trentina Di Muccio (Yazar), Ilaria Genovese (Yazar), Annarita Fiorillo (Yazar), Steven Harper (Yazar), Alberto Bresciani (Yazar), Gianni Colotti (Yazar), Andrea Ilari (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2018-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system of Leishmania to neutraliz...