Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro

• Autores principales: Weiping Ji (Autor), Jiquan Shen (Autor), Bo Wang (Autor), Feifei Chen (Autor), Deru Meng (Autor), Shuanghu Wang (Autor), Dapeng Dai (Autor), Yunfang Zhou (Autor), Changxiong Wang (Autor), Quan Zhou (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2021-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Context Dacomitinib and poziotinib, irreversible ErbB family blockers, are often used for treatment of non-small cell lung cancer (NSCLC) in the clinic. Objective This study investigates the effect of dacomitinib on the pharmacokinetics of poziotinib in rats. Materials and methods Twelve Sprague-Daw...