Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro

• Main Authors: Weiping Ji (Author), Jiquan Shen (Author), Bo Wang (Author), Feifei Chen (Author), Deru Meng (Author), Shuanghu Wang (Author), Dapeng Dai (Author), Yunfang Zhou (Author), Changxiong Wang (Author), Quan Zhou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Dacomitinib and poziotinib, irreversible ErbB family blockers, are often used for treatment of non-small cell lung cancer (NSCLC) in the clinic. Objective This study investigates the effect of dacomitinib on the pharmacokinetics of poziotinib in rats. Materials and methods Twelve Sprague-Daw...