Evaluation of polyelectrolyte and emulsion covalent crosslink of chitosan for producing mesalasine loaded submicron particles

• Main Authors: Gabriel José Silveira Lacerda (Author), Beatriz Lemos Piantino (Author), Edeilson Vitor Gonzaga (Author), Valéria de Moura Leite Naves (Author), Liliane Neves Pedreiro (Author), Maria Palmira Daflon Gremião (Author), Gislaine Ribeiro Pereira (Author), Flávia Chiva Carvalho (Author)
• Format: Book
• Published: Universidade de São Paulo, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical crosslinking of chitosan with genipin and (3) the water-in-oil emulsion meth...