NETUPITANT, A POTENT AND HIGHLY SELECTIVE NK1 RECEPTOR ANTAGONIST, ALLEVIATES ACETIC ACID-INDUCED BLADDER OVERACTIVITY IN ANESTHETIZED GUINEA-PIGS

• Main Authors: Stefano Palea (Author), Veronique Guilloteau (Author), Moez Rekik (Author), Emanuela Lovati (Author), Marc Guerard (Author), Maria-Alba Guardia (Author), Philippe Lluel (Author), Claudio Pietra (Author), Mitsuharu Yoshiyama (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Tachykinins potently contract the isolated urinary bladder from a number of animal species and play an important role in the regulation of the micturition reflex. On the guinea-pig isolated urinary bladder we examined the effects of a new potent and selective NK1 receptor antagonist (n...