Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

• Main Authors: Meng Zhao (Author), Saki Nakamura (Author), Takahito Miyake (Author), Kanako So (Author), Hisashi Shirakawa (Author), Shogo Tokuyama (Author), Minoru Narita (Author), Takayuki Nakagawa (Author), Shuji Kaneko (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin, a platinum-based chemotherapeutic agent, causes an acute peripheral neuropathy triggered by cold in almost all patients during or within hours after its infusion. We recently reported that a single administration of oxaliplatin induced cold hypersensitivity 2 h after the administration...