Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles

• Main Authors: Eugene P. Chung (Author), Jennifer D. Cotter (Author), Alesia V. Prakapenka (Author), Rebecca L. Cook (Author), Danielle M. DiPerna (Author), Rachael W. Sirianni (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alternative routes of administration are one approach that could be used to bypass the blood−brain barrier (BBB) for effective drug delivery to the central nervous system (CNS). Here, we focused on intranasal delivery of polymer nanoparticles. We hypothesized that surface modification of p...