High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel.

• Main Authors: Jessica Denis (Author), Sarah Attoumani (Author), Patrick Gravier (Author), Bernard Tenebray (Author), Annabelle Garnier (Author), Sébastien Briolant (Author), Franck de Laval (Author), Véronique Chastres (Author), Gilda Grard (Author), Isabelle Leparc-Goffart (Author), Bruno Coutard (Author), Cyril Badaut (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Zika virus (ZIKV) and Dengue virus (DENV) are often co-endemic. The high protein-sequence homology of flaviviruses renders IgG induced by and directed against them highly cross-reactive against their antigen(s), as observed on a large set of sera, leading to poorly rel...