Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect

• Main Authors: Jianxia Dong (Author), Shu Wang (Author), Jiamin Mao (Author), Zhidan Wang (Author), Shiying Zhao (Author), Qiao Ren (Author), Jialing Kang (Author), Jing Ye (Author), Xiaohong Xu (Author), Yujin Zhu (Author), Quan Zhang (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intraperitoneal injection of dihydromyricetin (DMY) has shown promising potential in the treatment of alcoholism. However, its therapeutic effect is limited due to its low solubility, poor stability, and high gut-liver first-pass metabolism, resulting in very low oral bioavailability. In this study,...