Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1

• Main Authors: Mengmeng Liang (Author), Xiaofan Yin (Author), Shuai Zhang (Author), Hongbo Ai (Author), Fei Luo (Author), Jianzhong Xu (Author), Ce Dou (Author), Shiwu Dong (Author), Qinyu Ma (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activated osteoclasts release large amounts of small extracellular vesicles (sEVs) during bone remodeling. However, little is known about whether osteoclast-derived sEVs affect surrounding cells. In this study, osteoclasts were generated by stimulating bone marrow macrophages (BMMs) with macrophage...