Eight pharmacokinetic genetic variants are not associated with the risk of bleeding from direct oral anticoagulants in non-valvular atrial fibrillation patients

• Main Authors: Alessandra M. Campos-Staffico (Author), Michael P. Dorsch (Author), Geoffrey D. Barnes (Author), Hao-Jie Zhu (Author), Nita A. Limdi (Author), Jasmine A. Luzum (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Atrial fibrillation (AF) is the leading cause of ischemic stroke and treatment has focused on reducing this risk through anticoagulation. Direct Oral Anticoagulants (DOACs) are the first-line guideline-recommended therapy since they are as effective and overall safer than warfarin in pre...