Acidosis activates complement system in vitro

• Main Authors: Michael Emeis (Author), Josef Sonntag (Author), Carsten Willam (Author), Evelyn Strauss (Author), Matthias M. Walka (Author), Michael Obladen (Author)
• Format: Book
• Published: Hindawi Limited, 1998-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12) caused significant activation of C3a and C5a...