Acidosis activates complement system in vitro

• Autori principali: Michael Emeis (Autore), Josef Sonntag (Autore), Carsten Willam (Autore), Evelyn Strauss (Autore), Matthias M. Walka (Autore), Michael Obladen (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 1998-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood (N=12) caused significant activation of C3a and C5a...