Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

• Main Authors: Alessio Nocentini (Author), Roberta Cadoni (Author), Pascal Dumy (Author), Claudiu T. Supuran (Author), Jean-Yves Winum (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar range. Preferential inhibitory potency agains...