Clinical Pharmacokinetics and Pharmacodynamics of Cerliponase Alfa, Enzyme Replacement Therapy for CLN2 Disease by Intracerebroventricular Administration

Clinical Pharmacokinetics and Pharmacodynamics of Cerliponase Alfa, Enzyme Replacement Therapy for CLN2 Disease by Intracerebroventricular Administration

Cerliponase alfa is recombinant human tripeptidyl peptidase 1 (TPP1) delivered by i.c.v. infusion for CLN2, a pediatric neurodegenerative disease caused by deficiency in lysosomal enzyme TPP1. We report the pharmacokinetics (PK) and pharmacodynamics of cerliponase alfa, the first i.c.v. enzyme repla...

Full description

Saved in:
Bibliographic Details
Main Authors: Aryun Kim (Author), Anita Grover (Author), Kevin Hammon (Author), Greg deHart (Author), Peter Slasor (Author), Anu Cherukuri (Author), Temitayo Ajayi (Author), David Jacoby (Author), Angela Schulz (Author), Nicola Specchio (Author), Emily deLos Reyes (Author), Paul Gissen (Author), Joshua W. Henshaw (Author)
Format: Book
Published: Wiley, 2021-03-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items