A Novel 2-Methoxyestradiol Derivative: Disrupting Mitosis Inhibiting Cell Motility and Inducing Apoptosis in HeLa Cells In Vitro

A Novel 2-Methoxyestradiol Derivative: Disrupting Mitosis Inhibiting Cell Motility and Inducing Apoptosis in HeLa Cells In Vitro

The clinical application of 2-methoxyestradiol (2ME) in cancer therapy has been limited by its low solubility and rapid metabolism. Derivatives of 2ME have been synthesised to enhance bioavailability and decrease hepatic metabolism. Compound <b>4a</b>, an analog of 2ME, has demonstrated...

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Main Authors: Isaac Kinyua Njangiru (Author), Noémi Bózsity-Faragó (Author), Vivien Erzsébet Resch (Author), Gábor Paragi (Author), Éva Frank (Author), György T. Balogh (Author), István Zupkó (Author), Renáta Minorics (Author)
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Published: MDPI AG, 2024-05-01T00:00:00Z.
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