Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization.

• Main Authors: Frédérique Vernel-Pauillac (Author), Gerald L Murray (Author), Ben Adler (Author), Ivo G Boneca (Author), Catherine Werts (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leptospira interrogans is a pathogenic spirochete responsible for leptospirosis, a neglected, zoonotic reemerging disease. Humans are sensitive hosts and may develop severe disease. Some animal species, such as rats and mice can become asymptomatic renal carriers. More than 350 leptospiral serovars...