A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

• Main Authors: Stan J. F. Hartman (Author), Joost G. E. Swaving (Author), Stijn W. van Beek (Author), Bianca D. van Groen (Author), Marika de Hoop (Author), Tjitske M. van der Zanden (Author), Rob ter Heine (Author), Saskia N. de Wildt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guideline...