The Inhibitory Effects of Aqueous Extract of Magnolia officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 Expression

• Main Authors: Byung-Cheol Lee (Author), Ho-Kyung Doo (Author), Hee-Jae Lee (Author), Sheng-Yu Jin (Author), Joo-Ho Jung (Author), Seung-Jae Hong (Author), Sang-Ho Lee (Author), Sung-Do Kim (Author), Jae-Kyung Park (Author), Kang-Hyun Leem (Author), Se-Young Ahn (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesangial cell (MC) proliferation, mediated by platelet-derived growth factor (PDGF)-BB, transforming growth factor (TGF)-β1, and cyclin-dependent kinases (CDK), is the common feature of glomerulosclerosis. Magnolia officinalis, stem bark of Machilus thunbergii S., has multiple pharmacological effec...