Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders

• Main Authors: Androulla N. Miliotou (Author), Ioannis S. Pappas (Author), George Spyroulias (Author), Efthimia Vlachaki (Author), Asterios S. Tsiftsoglou (Author), Ioannis S. Vizirianakis (Author), Lefkothea C. Papadopoulou (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the development of safe and efficient delivery platforms. In this study, an innov...