Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids

• Main Authors: Marie-Christin Jäger (Author), Víctor González-Ruiz (Author), Friedrich L. Joos (Author), Denise V. Winter (Author), Julien Boccard (Author), Thorsten Degenhardt (Author), Steve Brand (Author), Serge Rudaz (Author), George R. Thompson (Author), Alex Odermatt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism. Mechanisms underlying pseudohyperaldosteronism include inhibition of adrenal 11β-hydroxylase cytochrome...