Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids

• मुख्य लेखकों: Marie-Christin Jäger (लेखक), Víctor González-Ruiz (लेखक), Friedrich L. Joos (लेखक), Denise V. Winter (लेखक), Julien Boccard (लेखक), Thorsten Degenhardt (लेखक), Steve Brand (लेखक), Serge Rudaz (लेखक), George R. Thompson (लेखक), Alex Odermatt (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism. Mechanisms underlying pseudohyperaldosteronism include inhibition of adrenal 11β-hydroxylase cytochrome...