SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1

• Main Authors: Rajaa Sebaa (Author), Jeff Johnson (Author), Chantal Pileggi (Author), Michaela Norgren (Author), Jian Xuan (Author), Yuka Sai (Author), Qiang Tong (Author), Izabella Krystkowiak (Author), Emma Bondy-Chorney (Author), Norman E. Davey (Author), Nevan Krogan (Author), Michael Downey (Author), Mary-Ellen Harper (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a possible functional connection between UCP1 and s...