Present Scenario and Future Landscape of Payloads for ADCs: Focus on DNA-Interacting Agents

• Main Authors: Barbara Valsasina (Author), Paolo Orsini (Author), Chiara Terenghi (Author), Alberto Ocana (Author)
• Formato: Libro
• Publicado: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

ADCs have emerged as a promising class of therapeutics, combining the targeting specificity of monoclonal antibodies with the cytotoxic potency of small-molecule drugs. Although the majority of approved ADCs are still based on microtubule binder payloads, the recent success of topoisomerase I inhibi...