Cell cycle block by p53 activation reduces SARS-CoV-2 release in infected alveolar basal epithelial A549-hACE2 cells

• Главные авторы: Giada Lodi (Автор), Valentina Gentili (Автор), Fabio Casciano (Автор), Arianna Romani (Автор), Giorgio Zauli (Автор), Paola Secchiero (Автор), Enrico Zauli (Автор), Carolina Simioni (Автор), Silvia Beltrami (Автор), Mercedes Fernandez (Автор), Roberta Rizzo (Автор), Rebecca Voltan (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Предметы: article
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SARS-CoV viruses have been shown to downregulate cellular events that control antiviral defenses. They adopt several strategies to silence p53, key molecule for cell homeostasis and immune control, indicating that p53 has a central role in controlling their proliferation in the host. Specific action...