SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

• Main Authors: Kaixiang Zhu (Author), Lili Song (Author), Linyue Wang (Author), Lei Hua (Author), Ziyu Luo (Author), Tongyun Wang (Author), Bo Qin (Author), Shuofeng Yuan (Author), Xiaopan Gao (Author), Wenyi Mi (Author), Sheng Cui (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis. CUL2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase, is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity, leading to degradation of IFT46, a protein component of the intra...