SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis. CUL2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase, is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity, leading to degradation of IFT46, a protein component of the intra...
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Materiálatiipa: | Girji |
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Elsevier,
2024-09-01T00:00:00Z.
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