Gambogic acid inhibits tumor metastasis through blocking matrix metalloproteinases mediated TGF-β1 activation

• Main Authors: Bin Li (Author), Shaoxia Liu (Author), Bin Zhao (Author), Xiaoxian Huang (Author), Ze Zhao (Author), Zhongtao Zhang (Author), Yuting Zhao (Author), Feng Feng (Author), Jingwei Xue (Author), Fulei Liu (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: Tumor metastasis is the major death factor in cancer patients. Transforming growth factor-β (TGF-β) is an important cytokine promoting tumor metastasis and blocking TGF-β shows crucial antitumor application prospects. In the tumor microenvironment (TME), TGF-β is always highly activated and...