F199E substitution reduced toxicity of Clostridium perfringens epsilon toxin by depriving the receptor binding capability

• Main Authors: Jingjing Kang (Author), Jie Gao (Author), Wenwu Yao (Author), Lin Kang (Author), Shan Gao (Author), Hao Yang (Author), Bin Ji (Author), Ping Li (Author), Jing Liu (Author), Jiahao Yao (Author), Wenwen Xin (Author), Baohua Zhao (Author), Jinglin Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epsilon toxin (ETX), a potent toxin, is produced by types B and D strains of Clostridium perfringens, which could cause severe diseases in humans and domestic animals. Mutant rETXF199E was previously demonstrated to be a good vaccine candidate. However, the mechanism concerned remains unknown. To cl...