High-resolution genotyping of the endemic Salmonella Typhi population during a Vi (typhoid) vaccination trial in Kolkata.

• Main Authors: Kathryn E Holt (Author), Shanta Dutta (Author), Byomkesh Manna (Author), Sujit K Bhattacharya (Author), Barnali Bhaduri (Author), Derek J Pickard (Author), R Leon Ochiai (Author), Mohammad Ali (Author), John D Clemens (Author), Gordon Dougan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a major health problem especially in developing countries. Vaccines against typhoid are commonly used by travelers but less so by residents of endemic areas.We used single nucleotide polymorphism (SNP) typing to investigate th...