Inflammatory Cytokine Tumor Necrosis Factor-α Enhances Nerve Growth Factor Production in Human Keratinocytes, HaCaT Cells

• Main Authors: Koji Takaoka (Author), Yasuhito Shirai (Author), Naoaki Saito (Author)
• Format: Knjiga
• Izdano: Elsevier, 2009-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The skin lesions of inflammatory skin diseases (e.g., atopic dermatitis or psoriasis) accompany infiltration of inflammatory cells like macrophages, where abnormal sensory innervations and elevation of nerve growth factor (NGF) level are observed. It is thought that increased NGF mediates the abnorm...