Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase

• Main Authors: Ming-Hsien Chiang (Author), Chan-Jung Liang (Author), Chen-Wei Liu (Author), Bo-Jhih Pan (Author), Wen-Ping Chen (Author), Yi-Fan Yang (Author), I-Ta Lee (Author), Jaw-Shiun Tsai (Author), Chiang-Wen Lee (Author), Yuh-Lien Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aliskiren is a direct renin inhibitor that has been effective in anti-hypertension. We investigated whether aliskiren could improve the ischemia-induced cardiac injury and whether the autophagy was involved in this effect. A myocardial infarction (MI) model was created by the ligation of the left an...