Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway

• Main Authors: Heng Sun (Author), Ziying Sun (Author), Xingquan Xu (Author), Zhongyang Lv (Author), Jiawei Li (Author), Rui Wu (Author), Yuxiang Fei (Author), Guihua Tan (Author), Zizheng Liu (Author), Yuan Liu (Author), Dongquan Shi (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. Notedly, the ROS (reactive oxygen species) level in macrophages is intimately implicated in macrophage M1 polarization. TRPV4 (transient receptor pote...