Integrating machine learning with pharmacokinetic models: Benefits of scientific machine learning in adding neural networks components to existing PK models

• Үндсэн зохиолчид: Diego Valderrama (Зохиогч), Ana Victoria Ponce‐Bobadilla (Зохиогч), Sven Mensing (Зохиогч), Holger Fröhlich (Зохиогч), Sven Stodtmann (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wiley, 2024-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Recently, the use of machine‐learning (ML) models for pharmacokinetic (PK) modeling has grown significantly. Although most of the current approaches use ML techniques as black boxes, there are only a few that have proposed interpretable architectures which integrate mechanistic knowledge. I...