Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

• Glavni autori: Samantha L. Ginn (Autor), Claus V. Hallwirth (Autor), Sophia H.Y. Liao (Autor), Erdahl T. Teber (Autor), Jonathan W. Arthur (Autor), Jianmin Wu (Autor), Hong Ching Lee (Autor), Szun S. Tay (Autor), Min Hu (Autor), Roger R. Reddel (Autor), Matthew P. McCormack (Autor), Adrian J. Thrasher (Autor), Marina Cavazzana (Autor), Stephen I. Alexander (Autor), Ian E. Alexander (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2017-03-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

In early gene therapy trials for SCID-X1, using γ-retroviral vectors, T cell leukemias developed in a subset of patients secondary to insertional proto-oncogene activation. In contrast, we have reported development of T cell leukemias in SCID-X1 mice following lentivirus-mediated gene therapy indepe...