Active DNA Demethylase, TET1, Increases Oxidative Phosphorylation and Sensitizes Ovarian Cancer Stem Cells to Mitochondrial Complex I Inhibitor

• Main Authors: Lin-Yu Chen (Author), Yao-An Shen (Author), Ling-Hui Chu (Author), Po-Hsuan Su (Author), Hui-Chen Wang (Author), Yu-Chun Weng (Author), Shiou-Fu Lin (Author), Kuo-Chang Wen (Author), Phui-Ly Liew (Author), Hung-Cheng Lai (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ten-eleven translocation 1 (TET1) is a methylcytosine dioxygenase involved in active DNA demethylation. In our previous study, we demonstrated that TET1 reprogrammed the ovarian cancer epigenome, increased stem properties, and activated various regulatory networks, including metabolic networks. Howe...