New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies

• Main Authors: Romina A. Guedes (Author), Jorge H. Grilo (Author), Andreia N. Carvalho (Author), Pedro M. P. Fernandes (Author), Ana S. Ressurreição (Author), Vanessa Brito (Author), Adriana O. Santos (Author), Samuel Silvestre (Author), Eleonora Gallerani (Author), Maria João Gama (Author), Riccardo Gavioli (Author), Jorge A. R. Salvador (Author), Rita C. Guedes (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer is a complex multifactorial disease whose pathophysiology involves multiple metabolic pathways, including the ubiquitin-proteasome system, for which several proteasome inhibitors have already been approved for clinical use. However, the resistance to existing therapies and the occurrence of s...