Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent

• Main Authors: Seulgi Shin (Author), Sungsu Lim (Author), Ji Yeon Song (Author), Dohee Kim (Author), Min Jeong Choi (Author), Changdev G. Gadhe (Author), A Young Park (Author), Ae Nim Pae (Author), Yun Kyung Kim (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma drug development has been difficult due to the extremely low blood brain barrier (BBB) penetration of conventional anti-cancer agents. P-glycoprotein, an efflux membrane transporter, is responsible for the poor brain uptake of small and hydrophobic drug substances. To develop brain-pene...