Acute methotrexate toxicity managed with leucovorin and pegylated granulocyte colony-stimulating factor: A report of two cases and review of literature

• Main Authors: Shiva Shankar Marri (Author), Mohnish Sekar (Author), Keshavmurthy A Adya (Author), Arun C Inamadar (Author), Ajit B Janagond (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute methotrexate (MTX) toxicity is most commonly due to overdose of the drug, which may be due to the patient's noncompliance to doctor's orders or physician's prescription error. Other causes include acute renal failure, concomitant use of other drugs, and genetic susceptibility. M...