RA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis

• Main Authors: Nana Zheng (Author), Wenbo Zhang (Author), Xiaodan Zhang (Author), Biao Li (Author), Zhanying Wu (Author), Yashuang Weng (Author), Weiyong Wang (Author), Jingjing Miao (Author), Jing Yang (Author), Meijia Zhang (Author), Wei Xia (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Retinoic acid (RA) plays important role in the maintenance and differentiation of the Müllerian ducts during the embryonic stage via RA receptors (RARs). However, the function and mechanism of RA-RAR signaling in the vaginal opening are unknown. Method We used the Rarα knockout...