Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

• Main Authors: Joshua C. Peterson (Author), Mary Chughtai (Author), Lambertus J. Wisse (Author), Adriana C. Gittenberger-de Groot (Author), Qingping Feng (Author), Marie-José T. H. Goumans (Author), J. Conny VanMunsteren (Author), Monique R. M. Jongbloed (Author), Marco C. DeRuiter (Author)
• Format: Book
• Published: The Company of Biologists, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impa...