Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study

• Main Authors: Sreekanth Dittakavi (Author), Rakesh Kumar Jat (Author), Sadanand Rangnathrao Mallurwar (Author), Ravi Kumar Jairam (Author), Ramesh Mullangi (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of ivosidenib in mice plasma using warfarin as an internal standard (I.S.) as per regulatory guideline. Sample preparation was accomplished through a simple protein precipitation process. Chroma...