Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study

• 主要な著者: Sreekanth Dittakavi (著者), Rakesh Kumar Jat (著者), Sadanand Rangnathrao Mallurwar (著者), Ravi Kumar Jairam (著者), Ramesh Mullangi (著者)
• フォーマット: 図書
• 出版事項: International Association of Physical Chemists (IAPC), 2019-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A simple, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of ivosidenib in mice plasma using warfarin as an internal standard (I.S.) as per regulatory guideline. Sample preparation was accomplished through a simple protein precipitation process. Chroma...