Site-Specific Radiolabeling of a Human PD-L1 Nanobody via Maleimide-Cysteine Chemistry

• Main Authors: Dora Mugoli Chigoho (Author), Quentin Lecocq (Author), Robin Maximilian Awad (Author), Karine Breckpot (Author), Nick Devoogdt (Author), Marleen Keyaerts (Author), Vicky Caveliers (Author), Catarina Xavier (Author), Jessica Bridoux (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) and its ligand PD-L1 have proven to be efficient cancer therapies in a subset of patients. From all the patients with various cancer types, only 20% have a positive response. Being able to distinguish patients that do express...