Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

• Autori principali: Tulika Arora (Autore), Udo Wegmann (Autore), Anup Bobhate (Autore), Ying Shiuan Lee (Autore), Thomas U. Greiner (Autore), Daniel J. Drucker (Autore), Arjan Narbad (Autore), Fredrik Bäckhed (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2016-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (...