Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

• المؤلفون الرئيسيون: Tulika Arora (مؤلف), Udo Wegmann (مؤلف), Anup Bobhate (مؤلف), Ying Shiuan Lee (مؤلف), Thomas U. Greiner (مؤلف), Daniel J. Drucker (مؤلف), Arjan Narbad (مؤلف), Fredrik Bäckhed (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2016-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Objective: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (...