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Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice

Objective: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (...

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Main Authors: Tulika Arora (Author), Udo Wegmann (Author), Anup Bobhate (Author), Ying Shiuan Lee (Author), Thomas U. Greiner (Author), Daniel J. Drucker (Author), Arjan Narbad (Author), Fredrik Bäckhed (Author)
Format: Book
Published: Elsevier, 2016-08-01T00:00:00Z.
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